Skip to main content

First step to future vaccines? Mice that glow like fireflies

mice fireflies stanford 61467159 l
No, it’s not a deleted scene from The Island of Dr. Moreau; scientists at Stanford University really have come up with a way to make mice glow in the dark by producing firefly proteins. And it could just turn out to be a major advance in the development of future designer vaccines or even cancer therapies.

The research was described in a recent paper published in the journal Proceedings of the National Academy of Sciences.

“This study demonstrated for the first time that we can deliver messenger RNA (mRNA) to cells in a dish, or to cells in organs of living animals,” Professor Christopher Contag, one of the co-authors, told Digital Trends. “mRNA is the intermediate between the genome and functional proteins. Prior to this work there has not been an effective way to transfer synthetic mRNA into cells in a way that the cell can turn it into protein. This opens up an entirely new way to have cells express proteins that can treat a myriad of diseases.”

The work represents a significant advance in the ability of scientists to send mRNA through a cell membrane: something which poses a challenge due to the fact that mRNA is negatively charged, and therefore cannot easily sneak through a positively charged cell membrane.

To get around this, the scientists involved with this research came up with a positively charged delivery method. Once inside the cell, the mRNA then detaches from its transporter compound to manufacture proteins without any problems.

The reason for the mouse experiment was all about quickly demonstrating that the efforts had been a success.

“We needed a way of getting a readout to show that the material had made it to its destination as intended,” Professor Paul Wender, another co-author, told Digital Trends “What we did was to use mRNA that codes for an optical readout, meaning one that we could see. In this case that meant light coming out of a cell. It’s the fastest way of discovering whether you have succeeded in getting something into a cell, by getting it to shoot photons back at you.”

Not only did the mammalian cell successfully generate an insect protein in a way that was biologically active, but it also did so without the mouse suffering any ill effects — or even seemingly noticing anything was different.

“It was a temporary effect,” Wender said. “The protein production maximized after a few hours, and it plays out anywhere from 24-48 hours. For many therapeutic opportunities, this is exactly what you want. For example, if you or I were to have a headache that requires aspirin, it’s good that it only acts for 8-12 hours. If you were constantly under the influence of aspirin, there would be other undesirable consequences.”

He did, however, note that it could also prove possible to produce longer-lasting, persistent effects by going into the genome and altering DNA on a fundamental level.

It’s still early days for this research, but the possibility of mRNA transmission opens up some enormously exciting, life-altering possibilities in the years to come. And, when you’re talking about reprogramming cells, we mean “life-altering” in the literal sense.

Editors' Recommendations

Luke Dormehl
I'm a UK-based tech writer covering Cool Tech at Digital Trends. I've also written for Fast Company, Wired, the Guardian…
Why AI will never rule the world
image depicting AI, with neurons branching out from humanoid head

Call it the Skynet hypothesis, Artificial General Intelligence, or the advent of the Singularity -- for years, AI experts and non-experts alike have fretted (and, for a small group, celebrated) the idea that artificial intelligence may one day become smarter than humans.

According to the theory, advances in AI -- specifically of the machine learning type that's able to take on new information and rewrite its code accordingly -- will eventually catch up with the wetware of the biological brain. In this interpretation of events, every AI advance from Jeopardy-winning IBM machines to the massive AI language model GPT-3 is taking humanity one step closer to an existential threat. We're literally building our soon-to-be-sentient successors.

Read more
The best hurricane trackers for Android and iOS in 2022
Truck caught in gale force winds.

Hurricane season strikes fear into the hearts of those who live in its direct path, as well as distanced loved ones who worry for their safety. If you've ever sat up all night in a state of panic for a family member caught home alone in the middle of a destructive storm, dependent only on intermittent live TV reports for updates, a hurricane tracker app is a must-have tool. There are plenty of hurricane trackers that can help you prepare for these perilous events, monitor their progress while underway, and assist in recovery. We've gathered the best apps for following storms, predicting storm paths, and delivering on-the-ground advice for shelter and emergency services. Most are free to download and are ad-supported. Premium versions remove ads and add additional features.

You may lose power during a storm, so consider purchasing a portable power source,  just in case. We have a few handy suggestions for some of the best portable generators and power stations available. 

Read more
Don’t buy the Meta Quest Pro for gaming. It’s a metaverse headset first
Meta Quest Pro enables 3D modeling in mixed reality.

Last week’s Meta Connect started off promising on the gaming front. Viewers got release dates for Iron Man VR, an upcoming Quest game that was previously a PS VR exclusive, as well as Among Us VR. Meta, which owns Facebook, also announced that it was acquiring three major VR game studios -- Armature Studio, Camouflaj Team, and Twisted Pixel -- although we don’t know what they’re working on just yet.

Unfortunately, that’s where the Meta Connect's gaming section mostly ended. Besides tiny glimpses and a look into fitness, video games were not the show's focus. Instead, CEO Mark Zuckerberg wanted to focus on what seemed to be his company’s real vision of VR's future, which involves a lot of legs and a lot of work with the Quest Pro, a mixed reality headset that'll cost a whopping $1,500.

Read more