Skip to main content

Doctors could one day diagnose Alzheimer’s with a simple eye exam

It’s hard to overstate how devastating neurodegenerative diseases like Alzheimer’s can be. But while there is no cure for Alzheimer’s yet, early diagnosis that results in earlier treatment can help to delay its progression. Today, a doctor diagnosing Alzheimer’s would likely do so through a combination of memory tests, blood tests (to rule out other reasons for memory being affected), and a CT scan. However, in the future it could conceivably be as simple as carrying out a relatively basic eye test. This may speed up diagnosis since it could show positive results before the onset of symptoms.

“[In our new work] we found evidence of neurofilament light chain (NfL) in eye fluid,” Manju Subramanian, an ophthalmologic surgeon at Boston Medical Center, told Digital Trends. “Increased levels of NfL are detectable in blood and cerebrospinal fluid in conditions such as Alzheimer’s and Parkinson’s Disease.”

Related Videos

Subramanian noted that it is too early to confirm if the eye could indeed be a source of diagnosis, although she described this as a “foundational” study for such work to be explored later on. The Boston Medical Center study is the first time that NfL, which is biomarker for diagnosis of certain neurodegenerative diseases, has been found in the eye.

“The eye is an extension of the brain, and as an optical system, the eye can provide a direct window to visualize disease,” she said. “Many diseases that affect the central nervous system can also affect the eye. As such, direct sampling of ocular fluid for quantification of biomarkers may provide a uniquely accessible and cost-effective means for diagnosis.”

The researchers in the study collected eye fluid samples from 77 patients undergoing eye surgery at Boston Medical Center. All 77 patients tested positive for the presence of NfL.

Neurodegenerative diseases are currently on the rise around the world as many people are living longer than before. Alzheimer’s remains the most common disease in this category, affecting around 5.5 million Americans today. Parkinson’s is less common, but still affects over one million people in the United States. It’s too early to jump to conclusions about how this work could potentially impact these numbers. However, every piece of research in this area represents a step in the right direction. This is definitely research to follow.

A paper describing the work was recently published in the journal Alzheimer’s Research & Therapy.

Editors' Recommendations

We could soon be coughing into our phones to see if we have COVID-19
google search can now teach you how to pronounce tricky words speaker phone

Imagine if you could open an app on your smartphone and simply cough to discover right there and then if you have COVID-19.

Researchers at the Massachusetts Institute of Technology (MIT) say they have developed such a method, which could be used as part of broader measures to get the virus under control.

Read more
Don’t drop your diet yet, but scientists have discovered how CRISPR can burn fat

A personalized therapy for metabolic conditions that are linked to obesity could involve removing a small amount of a person’s fat, transforming it into an energy-burning variation using CRISPR gene-editing, and then re-implanting it into the body, according to researchers from the University of Massachusetts Medical School.

In tests involving mice, the implanted human fat cells helped lower sugar concentrations in the blood and decrease fat in the liver. When the mice were put on a high-fat diet, the ones that had been implanted with the human beige fat only gained half as much weight as those that had been implanted with regular human fat.

Read more
Sniffer dogs could detect COVID-19 days before symptoms occur
sniffer dogs detecting covid 19 in people is a thing dog training

Scientists have discovered that dogs’ powerful sense of smell can enable the animal to sniff out COVID-19 on infected people even before they develop symptoms.

The global research efforts have so far led to two international airports deploying trained sniffer dogs in trials aimed at tracking down travelers with the virus as they pass through the facility.

Read more