New York is split into three different zones in the upcoming Prototype 2. Green is the safe, relatively normal area, yellow has more military and the occasional outbreak of infected and the red zone is the “we gave up” area where the infection has pretty much completely taken over.
In this developer diary they explore the three areas and explain how the zones should feel for players. This video specifically explores the green zone and discusses some of the story elements that new protagonist Jack Heller will encounter.
Activision has slated Prototype 2 to be released on April 24, 2012 for Xbox 360 and Playstation 3.