While presenting their research at the American Chemical Society’s meeting, Lu noted, “We are working on a solution to improve surgical cancer treatments. Removing spinal tumors sometimes requires removing surrounding bone/discs. We’ve created a spongy cage to fill the void in the spine.”
The polymer works much like those playful sponges of our childhood — the ones that we dropped in cups of water in order to turn them from capsules into dinosaurs or other animal shapes. Of course, these new biodegradable polymers would serve a much more serious purpose. Derived from a dehydrated hydrogel, surgeons would simply plant these capsules into gaps in the spinal cord (resulting from either surgery or another injury), and our body’s fluids would then activate the polymer, allowing them to expand to the proper proportions.
Both scientists believe that this new technique will be particularly valuable for cancer patients, as the spine is often affected when cancerous cells metastasize. Currently, in order to address spinal tumors, surgeons are forced to remove large portions of the bone, sometimes even entire discs, leaving gaping holes that then must be filled. Metal spine cages and bone grafts are the present solution to these cavities, but they’re certainly not ideal, especially given the long healing process. But with this new polymer, which could expand in just five to ten minutes, we may have an extremely attractive alternative.
Testing on cadavers is slated to begin in the near future, and both Lu and Liu are confident about results. “[The polymer] needs to support the body weight of the patient,” Liu said. “This polymer is very strong and we believe it will hold up.”
If all goes well, clinical trials could commence within the next few years, and the way we address spinal cord injuries could shift forever.
- Modified silk could be used to repair damaged spinal cords
- Stretchy, flexible fibers offer a route to spinal cord recovery
- Surprisingly flexible 3D-printed bones could be used for treating fractures