Skip to main content

CRISPR gene editing could help stop a common poultry virus in its tracks

 

Researchers at the Czech Academy of Sciences may have successfully used CRISPR gene editing to create chickens that are resistant to avian leukosis virus (ALV), a common but deadly affliction that affects poultry with symptoms ranging from emaciation and dehydration to depressed behavior. This latest advance could potentially be a game changer when it comes to chicken welfare, with clear implications for meat and egg production around the world.

Recommended Videos

The ALV-J subgroup virus binds to a protein called chicken NHE-1 (chNHE-1). Replication of this virus depends on a functional chNHE-1 cellular receptor. In previous work, the researchers showed that it is possible to prevent ALV from infecting chicken cells by deleting three letters from the chNHE-1 gene. But in their newer work, they have created a young rooster with sperm that has the exact chNHE-1 gene deletion. Its offspring was a flock of white leghorn chickens with the deletion in both copies of the gene. “It’s quite simple to do,” Jiri Hejnar, the lead researcher on the project, told New Scientist.

Please enable Javascript to view this content

“Deletion of W38 did not manifest any visible side effect,” the researchers note in an abstract for a recent paper, published in PNAS, that describes the work. “Our data clearly demonstrate the antiviral resistance conferred by precise CRISPR/Cas9 gene editing in the chicken. Furthermore, our highly efficient CRISPR/Cas9 gene editing in primordial germ cells represents a substantial addition to genotechnology in the chicken, an important food source and research model.”

A company called Biopharm is reportedly in talks with poultry producers in Vietnam. They could introduce this genetic tweak into their commercial breeds. The researchers next plan to tackle other bird-related viruses, which could include ones that are potentially deadly to humans.

As impressive as this is, it isn’t the only use of CRISPR gene editing we’ve covered with the potential to cure disease. Other researchers have shown that it is possible to use gene editing to disable the defective gene that causes ALS in mice. Recently, researchers from the University of California — San Diego School of Medicine also suggested that it may be possible to use a new genetic-sequencing approach to create a “kill switch” to clear out dormant HIV reservoirs inside cells.

Luke Dormehl
Former Digital Trends Contributor
I'm a UK-based tech writer covering Cool Tech at Digital Trends. I've also written for Fast Company, Wired, the Guardian…
Hyundai Ioniq 5 sets world record for greatest altitude change
hyundai ioniq 5 world record altitude change mk02 detail kv

When the Guinness World Records (GWR) book was launched in 1955, the idea was to compile facts and figures that could finally settle often endless arguments in the U.K.’s many pubs.

It quickly evolved into a yearly compilation of world records, big and small, including last year's largest grilled cheese sandwich in the world.

Read more
Global EV sales expected to rise 30% in 2025, S&P Global says
ev sales up 30 percent 2025 byd sealion 7 1stbanner l

While trade wars, tariffs, and wavering subsidies are very much in the cards for the auto industry in 2025, global sales of electric vehicles (EVs) are still expected to rise substantially next year, according to S&P Global Mobility.

"2025 is shaping up to be ultra-challenging for the auto industry, as key regional demand factors limit demand potential and the new U.S. administration adds fresh uncertainty from day one," says Colin Couchman, executive director of global light vehicle forecasting for S&P Global Mobility.

Read more
Faraday Future could unveil lowest-priced EV yet at CES 2025
Faraday Future FF 91

Given existing tariffs and what’s in store from the Trump administration, you’d be forgiven for thinking the global race toward lower electric vehicle (EV) prices will not reach U.S. shores in 2025.

After all, Chinese manufacturers, who sell the least expensive EVs globally, have shelved plans to enter the U.S. market after 100% tariffs were imposed on China-made EVs in September.

Read more