Skip to main content

CRISPR gene editing may have just become a whole lot more accurate

CRISPR gene editing is an enormously exciting area for molecular biologists, opening up new opportunities when it comes to editing DNA to fight back against a wide range of medical conditions. Heck, it’s so versatile that it can even be used to encode a GIF into the DNA of a virus, demonstrating how it is possible to capture complex information in living bacteria.

If CRISPR (clustered regularly interspaced short palindronic repeats) wasn’t already exciting enough, however, it could be about to become even more of a highly prized tool in the hands of researchers. At McGill University in Montreal, researchers in Uri David Akavia’s team have demonstrated CRISPR’s best success rate yet: managing to repair mutations in 90 percent of target cells.

Recommended Videos

That is particularly significant because, while CRISPR is very good at disabling certain genes (in one recent experiment it was able to disable the defective gene that triggers ALS in mice), it is much harder to use CRISPR to fix genes. This approach, which usually works in under 10 percent of target cells, involves replacing a faulty DNA with another working sequence. Until now, the highest success rate was 60 percent, meaning that the McGill University team has performed significantly better.

In order to increase the efficiency of the CRISPR technique, Akavia’s team physically linked the replacement DNA with the CRISPR protein which finds and removes the faulty sequence, as well as using a polymer called polyethyleneimine to directly target the nucleus of the cells — thereby reducing waste.

Going forward, the technique could conceivably be used for treating or eliminating entirely all inherited diseases. This is something previous CRISPR work has sought to do but could be revolutionized by this more successful approach. However, before too many champagne corks are popped, the team will need to demonstrate efficacy on a wide range of cells to show that their approach is versatile and repeatable under different conditions. We’ll keep our fingers firmly crossed!

“Our approach offers a cost-effective, simple and broadly applicable editing method, thereby expanding the CRISPR/Cas9 genome editing toolbox,” the researchers note in a paper describing the work. The research paper is available to read on biological sciences online repository, bioRxiv.

Luke Dormehl
I'm a UK-based tech writer covering Cool Tech at Digital Trends. I've also written for Fast Company, Wired, the Guardian…
Sebastian Stan lays out Bucky’s future after Thunderbolts
Sebastian Stan in Thunderbolts.

There are some spoilers ahead for the ending of Marvel's Thunderbolts. Stop reading now if you don't want to be spoiled.

Earlier this year, Captain America: Brave New World briefly introduced a new direction for James "Bucky" Barnes, a character Sebastian Stan has been playing since 2011 in Captain America: The First Avenger. In Brave New World, the former Winter Soldier apparently retired from being a reformed hero and went into politics by running for Congress. Thunderbolts reveals that Bucky won his election to the House of Representatives. But his stay in Congress was short.

Read more
Jeep Compass EV breaks cover—but will it come to the U.S.?
jeep compass ev us newjeepcompassfirsteditionhawaii  4

Jeep just pulled the wraps off the all-new Compass EV, and while it’s an exciting leap into the electric future, there's a catch—it might not make it to the U.S. anytime soon.
This is a brand new electric version of the Jeep Compass, and being built on Stellantis' STLA platform—the same architecture underpinning models like the Peugeot E-3008 and E-5008—it looks much slicker and packs a lot more inside than previous versions of the Compass.
Let’s start with what’s cool: the new Compass EV is packing up to 404 miles of range on a single charge, a 74 kWh battery, and fast-charging that gets you from 20% to 80% in about 30 minutes. Not bad for a compact SUV with Jeep's badge on the nose.
There are two versions: a front-wheel-drive model with 213 horsepower and a beefier all-wheel-drive version with 375 horsepower. That AWD setup isn’t just for looks—it can handle 20% inclines even without front traction, and comes with extra ground clearance and better off-road angles. In short, it’s still a Jeep.
The design's been refreshed too, and inside you’ll find the kind of tech and comfort you’d expect in a modern EV—sleek, smart, and ready for both city streets and dirt trails.
But here’s the thing: even though production starts soon in Italy, Jeep hasn’t said whether the Compass EV is coming to America. And the signs aren’t promising.
Plans to build it in Canada were recently put on hold, with production now delayed until at least early 2026. Some of that might have to do with possible U.S. tariffs on Canadian and Mexican vehicles—adding a layer of uncertainty to the whole rollout.
According to Kelley Blue Book, a Stellantis spokesperson confirmed that the company has “temporarily paused work on the next-generation Jeep Compass, including activities at” the Canadian plant that was originally meant to build the model. They added that Stellantis is “reassessing its product strategy in North America” to better match customer needs and demand for different powertrain options.
So while Europe and other markets are gearing up to get the Compass EV soon, American drivers might be left waiting—or miss out entirely.
That’s a shame, because on paper, this electric Jeep hits a lot of sweet spots. Let’s just hope it finds a way over here.

Read more
Charlie Cox singles out his least favorite Daredevil: Born Again episode
Charlie Cox in Daredevil: Born Again.

Daredevil: Born Again season 1 was largely reconceived after the 2023 actor and writer strikes. Dario Scardapane -- a veteran of The Punisher series on Netflix -- was brought in to be the new showrunner and he made a lot of changes to the series that were well-received. However, there's one episode that Scardapane didn't really change at all, and it happens to be the least favorite episode of Daredevil: Born Again's leading man, Charlie Cox.

During an appearance on The Playlist, Cox noted that he wasn't very fond of the season's fifth episode, "With Interest," which was a largely standalone episode that featured his character, Matt Murdock, in a bank during a hostage crisis.

Read more